Inspired by Nobel-Level Science. Delivered with Concierge-Level Care
Following in the footsteps of the 2025 Nobel Prize in Medicine for immune tolerance, EXOPYR translates breakthrough science into measurable inflammation recovery – coming soon to those who refuse to wait decades for change.
Just as Apple transforms complexity into simplicity, EXOPYR turns the world’s most advanced inflammation science into an elegant experience that’s measurable, effortless, and potentially life changing.
Inspired by Nobel-Level Science. Delivered with Concierge-Level Care
Following in the footsteps of the 2025 Nobel Prize in Medicine for immune tolerance, EXOPYR translates breakthrough science into measurable inflammation recovery – coming soon to those who refuse to wait decades for change.
Just as Apple transforms complexity into simplicity, EXOPYR turns the world’s most advanced inflammation science into an elegant experience that’s measurable, effortless, and potentially life changing.
Inspired by Nobel-Level Science. Delivered with Concierge-Level Care
Following in the footsteps of the 2025 Nobel Prize in Medicine for immune tolerance, EXOPYR translates breakthrough science into measurable inflammation recovery – coming soon to those who refuse to wait decades for change.
Just as Apple transforms complexity into simplicity, EXOPYR turns the world’s most advanced inflammation science into an elegant experience that’s measurable, effortless, and potentially life changing.
About
The Innovative Company Behind the Inflammation Revolution
EXOPYR™ is a health innovation company redefining how inflammation is understood, measured, and resolved. Founded by Dr. Justin Mandel, DOM, EXOPYR bridges Eastern medicine principles of natural treatment with modern science to create measurable, lasting transformations in human health.
Its proprietary inflammation framework aligns with the same immune-tolerance science that just won the 2025 Nobel Prize – translating laboratory discoveries into concierge-level care that restores balance, longevity, and vitality.
Concierge Oversight
Licensed clinicians. Personalized precision.
Concierge Oversight
Licensed clinicians. Personalized precision.
Our Flagship Innovation: Extinguish Inflammation™
From Discovery to Application: The World’s First Concierge Inflammation Reset
Extinguish Inflammation™ is an eight-week, patent-pending protocol that measures and resets inflammation on four biological levels – systemic, cellular, genetic, and repair.
Guided by licensed functional medicine physicians, each client receives personalized oversight and Core-4 Lab testing (hs-CRP, fasting insulin, homocysteine, and uric acid) before and after their reset.
At EXOPYR , we are proud to share our impact on the community through healthcare services.
All protocols are designed with oversight from our founder whose urinary bladder clinical research has been exhaustively reviewed by Harvard, Duke, Johns Hopkins, and Emory, ensuring experience with the highest standards of clinical research and scientific integrity.
At EXOPYR , we are proud to share our impact on the community through healthcare services.
All protocols are designed with oversight from our founder whose urinary bladder clinical research has been exhaustively reviewed by Harvard, Duke, Johns Hopkins, and Emory, ensuring experience with the highest standards of clinical research and scientific integrity.
SCIENCE & RESEARCH
From Nobel Benchmarks to Real-World Results
The 2025 Nobel Prize in Medicine honored discoveries proving how the body’s immune system can achieve tolerance, preventing it from attacking itself.
EXOPYR builds upon those same principles of immune regulation, developing real-world frameworks that reduce inflammatory burden and re-establish biological balance through measurable, data-driven care.
Our research and innovation pipeline includes:
Inflammation Science & Immune Tolerance
Mitochondrial Optimization
Cellular Repair Chemistry
All-Natural Nutraceutical Stack
In addition to his clinical expertise, Dr. Mandel served as Chief Operating Officer and cofounder of Global Medical Innovations, LLC, a surgical medical device company established with a Harvard-trained physician. During his near-decade tenure, he helped lead the development, medical device design, and commercialization of innovations in post-surgical care.
Our research and innovation pipeline includes:
Inflammation Science & Immune Tolerance
Mitochondrial Optimization
Cellular Repair Chemistry
All-Natural Nutraceutical Stack
In addition to his clinical expertise, Dr. Mandel served as Chief Operating Officer and cofounder of Global Medical Innovations, LLC, a surgical medical device company established with a Harvard-trained physician. During his near-decade tenure, he helped lead the development, medical device design, and commercialization of innovations in post-surgical care.
Corporate Wellness
Where Science Meets Workplace Performance
Inflammation isn’t just a medical issue; it’s an economic one. EXOPYR partners with forward-thinking organizations to bring measurable health optimization into corporate wellness programs.
Our ROI-backed data shows reduced absenteeism, higher productivity, and improved cognitive performance – all tracked through verified biomarker improvements.
Corporate Wellness
Where Science Meets Workplace Performance
Inflammation isn’t just a medical issue; it’s an economic one. EXOPYR partners with forward-thinking organizations to bring measurable health optimization into corporate wellness programs.
Our ROI-backed data shows reduced absenteeism, higher productivity, and improved cognitive performance – all tracked through verified biomarker improvements.
LEADERSHIP
Meet the Innovator Behind the Framework
Dr. Justin Mandel, DOM
Founder & CEO of EXOPYR, LLC
Dr. Justin Mandel, DOM, is the founder of EXOPYR, LLC and creator of the Extinguish Inflammation™ protocol. As a Doctor of Oriental Medicine with a proven record of pioneering contributions, he was recognized by PayPath.com as their “Pick to Watch.” His mission is to positively impact the health and longevity of over one million patients worldwide.
Before developing EXOPYR’s revolutionary inflammation framework, Dr. Mandel spent over 23 years in clinical practice, beginning his first internship in 1997 and personally performing more than 70,000 treatments. That extensive experience led to his research that revealed what most medical models overlook: that inflammation operates across multiple biological layers, and no single supplement or treatment can resolve it alone.
His career spans the invention of diagnostic and treatment systems, a liquid topical, a medical device for surgical patients, and a biotechnology app — all within urology, surgical drainage, orthopedic innovation, pain relief, and digital health.
Dr. Justin Mandel, DOM, is the founder of EXOPYR, LLC and creator of the Extinguish Inflammation™ protocol. As a Doctor of Oriental Medicine with a proven record of pioneering contributions, he was recognized by PayPath.com as their “Pick to Watch.” His mission is to positively impact the health and longevity of over one million patients worldwide.
Before developing EXOPYR’s revolutionary inflammation framework, Dr. Mandel spent over 23 years in clinical practice, beginning his first internship in 1997 and personally performing more than 70,000 treatments. That extensive experience led to his research that revealed what most medical models overlook: that inflammation operates across multiple biological layers, and no single supplement or treatment can resolve it alone.
His career spans the invention of diagnostic and treatment systems, a liquid topical, a medical device for surgical patients, and a biotechnology app — all within urology, surgical drainage, orthopedic innovation, pain relief, and digital health.
Dr. Justin Mandel, DOM
Founder & CEO of EXOPYR, LLC
Our research and innovation pipeline includes:
Overactive Bladder Breakthrough — Inventor of the patented Bladder RE-EXPANSION Technique®, reviewed by Harvard, Johns Hopkins, Duke, and Emory.
Innovator in Pain Relief — Creator of TrapEAZE Technique® and formulator of FastEAZE14™, a 37-compound herbal topical.
Digital Health Pioneer — Co-launched Tubiit™, a biotech app that monitors post-hospital recovery, now under review for insurer adoption.
Digital Health Pioneer — Co-launched Tubiit™, a biotech app that monitors post-hospital recovery, now under review for insurer adoption
All protocols are designed with oversight from our founder whose urinary bladder clinical research has been exhaustively reviewed by Harvard, Duke, Johns Hopkins, and Emory, ensuring experience with the highest standards of clinical research and scientific integrity.
MEDIA INQUIRIES
Press & Speaking Engagements
EXOPYR welcomes inquiries from journalists, producers, and conference organizers seeking insight into the future of inflammation science, immune tolerance, and wellness innovation.
MEDIA INQUIRIES
Press & Speaking Engagements
EXOPYR welcomes inquiries from journalists, producers, and conference organizers seeking insight into the future of inflammation science, immune tolerance, and wellness innovation.