- 864-MY-RESET
- Inquiries@EXOPYR.com
Inflammation Is a System, Not A Symptom
Inspired by Nobel-Level Science. Delivered with Concierge-Level Care.
Introducing the world’s first luxury inflammation reset designed for executives, high achievers, and visionaries who refuse to settle for “average wellness.”
Developed by Dr. Justin Mandel, DOM, one of America’s leading healthcare innovators recognized by PayPath.com as their “Pick to Watch”. Exopyr’s Extinguish Inflammation™ program fuses medical precision with the refinement of concierge care.
Only 20 private clients accepted each week worldwide.
Inspired by Nobel-Level Science. Delivered with Concierge-Level Care.
Introducing the world’s first luxury inflammation reset designed for executives, high achievers, and visionaries who refuse to settle for “average wellness.”
Developed by Dr. Justin Mandel, DOM, one of America’s leading healthcare innovators recognized by PayPath.com as their “Pick to Watch”. Exopyr’s Extinguish Inflammation™ program fuses medical precision with the refinement of concierge care.
Only 20 private clients accepted each week worldwide.
Inspired by Nobel-Level Science. Delivered with Concierge-Level Care.
Introducing the world’s first luxury inflammation reset designed for executives, high achievers, and visionaries who refuse to settle for “average wellness.”
Developed by Dr. Justin Mandel, DOM, one of America’s leading healthcare innovators recognized by PayPath.com as their “Pick to Watch”. Exopyr’s Extinguish Inflammation™ program fuses medical precision with the refinement of concierge care.
Only 20 private clients accepted each week worldwide.
About
The Science of Precision. The Standard of Luxury.
True precision care begins where standard medicine stops. Every formula, every protocol, and every test is designed to deliver measurable transformation — from inflammation control to cellular renewal.
Most wellness programs focus on managing symptoms. We measure transformation.
At the heart of EXOPYR™ is lab-verified inflammation reduction tracked across four levels of your biology:
- Systemic → Restoring balance throughout the body
- Cellular → Reducing oxidative stress at the source
- Genetic → Reawakening healthy expression patterns
- Repair → Accelerating recovery and resilience
Because true health isn’t a trend — it’s a measurable evolution.
Precision Science
Every program begins with EXOPYR Core Panel Lab™ biomarker testing — objective, measurable data that defines your baseline and quantifies your results.
Clinical Integrity
Each case is reviewed by a licensed clinician from our national advisory network to ensure medical precision and safety.
Cellular Renewal
Our proprietary protocol extinguishes inflammation across all four biological levels, not just the one your doctor may have told you about.
Concierge Experience
From your first consult to your white-glove 8-week reset kit delivery, every step is handled with discretion, care, and efficiency.
Precision Science
Every program begins with Core-4 Lab™ biomarker testing — objective, measurable data that defines your baseline and quantifies your results.
Clinical Integrity
Each case is reviewed by a licensed clinician from our national advisory network to ensure medical precision and safety.
Cellular Renewal
Our proprietary protocol extinguishes inflammation across all four biological levels, not just the one your doctor may have told you about.
Concierge Experience
From your first consult to your white-glove 8-week reset kit delivery, every step is handled with discretion, care, and efficiency.
Our Flagship Innovation: Extinguish Inflammation™
From Discovery to Application: The World’s First Concierge Inflammation Reset
Extinguish Inflammation™ is an eight-week, patent-pending protocol that measures and resets inflammation on four biological levels – systemic, cellular, genetic, and repair.
This isn’t another anti-inflammatory program — it’s a total redefinition of how inflammation is measured, reversed, and verified through data.
Guided by licensed functional medicine physicians, each client receives personalized oversight and EXOPYR Core Panel Lab™
testing (hs-CRP, fasting insulin, homocysteine, and uric acid) before and after their reset.
At EXOPYR , we are proud to share our impact on the community through healthcare services.
All protocols are created with oversight from our founder whose urinary bladder clinical research has been exhaustively reviewed by Harvard, Duke, Johns Hopkins, and Emory, ensuring experience with the highest standards of clinical research and scientific integrity.
At EXOPYR , we are proud to share our impact on the community through healthcare services.
All protocols are created with oversight from our founder whose urinary bladder clinical research has been exhaustively reviewed by Harvard, Duke, Johns Hopkins, and Emory, ensuring experience with the highest standards of clinical research and scientific integrity.
Your Concierge Reset Journey
Every client begins a guided process designed for clarity, ease, and measurable results.
| Stage | Focus | Experience |
|---|---|---|
| Discovery | Private application & assessment | Ensures you’re an ideal fit for our concierge reset |
| Precision Testing | Core 5 biomarker labs | Drawn via mobile phlebotomy or your preferred local lab |
| White-Glove Delivery | Concierge Reset Kit arrives | Nutraceuticals, guided audios & client dashboard access |
| Proof of Change | Clinician review of before/after labs | Your results, quantified and explained |
| Renewal | Ongoing support options | Maintain and extend your gains year-round |
Corporate Wellness
Precision Health for High-Performance Organizations
At EXOPYR, we help forward-thinking companies safeguard their most valuable asset — their people. Our Extinguish Inflammation™ Corporate Reset is designed for executives, leadership teams, and high-performance employees who demand more than traditional wellness programs.
When executives perform at their peak, companies thrive. EXOPYR partners with leadership teams to optimize clarity, energy, and performance through measurable inflammation control.
This isn’t a one-size-fits-all health perk. It’s a lab-verified, doctor-developed precision program that identifies and addresses inflammation – the root cause behind fatigue, burnout, and declining productivity.
Through a white-glove onboarding process, each participating executive receives:
- Comprehensive inflammation biomarker testing
- Personalized nutraceutical and nutrition strategy
- Concierge coordination for labs and logistics
- Progress metrics that prove ROI — from sharper focus to stronger resilience
“When performance and clarity matter most, inflammation is the silent variable that determines both.”
LEADERSHIP
Meet the Founder
Dr. Justin Mandel, DOM – Founder & CEO of EXOPYR, LLC
Dr. Justin Mandel, DOM, is the Founder and CEO of EXOPYR, LLC, and creator of the Extinguish Inflammation™ protocol, a breakthrough concierge health framework redefining how inflammation is treated across the body’s four biological layers.
Recognized by PayPath.com as their “Pick to Watch,” Dr. Mandel’s mission is to improve the health and longevity of over one million people worldwide.
Before developing EXOPYR’s pioneering inflammation system, Dr. Mandel spent more than 23 years in clinical practice, beginning his first internship in 1997 and personally performing over 70,000 treatments. Based on extensive research to reverse his own personal systematic inflammation, he uncovered what most medical models overlook: inflammation operates on multiple levels – systemic, genetic, cellular, and repair – and no single intervention can extinguish it alone.
LEADERSHIP
Meet the Founder
Dr. Justin Mandel, DOM – Founder & CEO of EXOPYR, LLC
Dr. Justin Mandel, DOM, is the Founder and CEO of EXOPYR, LLC, and creator of the Extinguish Inflammation™ protocol, a breakthrough concierge health framework redefining how inflammation is treated across the body’s four biological layers.
Recognized by PayPath.com as their “Pick to Watch,” Dr. Mandel’s mission is to improve the health and longevity of over one million people worldwide.
Before developing EXOPYR’s pioneering inflammation system, Dr. Mandel spent more than 23 years in clinical practice, beginning his first internship in 1997 and personally performing over 70,000 treatments. Based on extensive research to reverse his own personal systematic inflammation, he uncovered what most medical models overlook: inflammation operates on multiple levels – systemic, genetic, cellular, and repair – and no single intervention can extinguish it alone.
In addition to his clinical expertise, Dr. Mandel served as Chief Operating Officer and cofounder of Global Medical Innovations, LLC, a surgical medical device company established with a Harvard-trained physician. During his near-decade tenure, he helped lead the development, medical device design, and commercialization of innovations in post-surgical care.
In addition to his clinical expertise, Dr. Mandel served as Chief Operating Officer and cofounder of Global Medical Innovations, LLC, a surgical medical device company established with a Harvard-trained physician. During his near-decade tenure, he helped lead the development, medical device design, and commercialization of innovations in post-surgical care.
His career spans diagnostic and treatment innovation, medical device development, pain relief formulation, and digital health technology, all with one unifying goal — creating science-backed systems that restore function and extend vitality.
Leading Achievements
- Overactive Bladder Breakthrough - Inventor of the patented Bladder RE-EXPANSION Technique®, the world’s first OAB rehabilitation procedure reviewed by Harvard, Johns Hopkins, Duke, and Emory.
- Innovator in Pain Relief - Developer of TrapEAZE Technique® and formulator of FastEAZE14™, 37-bioactive ingredients herbal topical for muscle and joint relief.
- Patient-Centered Medical Device - Co-developer of the post durgical drainage belt system Freedom Belt®, awarded “Best Choice Winner” by TopDust.com.
- Digital Health Pioneer - Co-launched Tubiit™, a biotech app monitoring post-hospital recovery, now under insurer review for national rollout.
“From the Hamptons to boardrooms to Billionaire’s Row, Dr. Mandel understands the lifestyle of those who demand more – and he built Extinguish Inflammation™ to meet that standard.”
For additional background and credentials, Dr. Mandel’s professional profile is available on LinkedIn.
From the Desk of Dr. Justin Mandel, DOM
Whose bladder research Harvard found “intriguing”, now leading the next evolution in inflammation science.
A message on the future of inflammation medicine and EXOPYR’s mission to unify diagnostics, biology, and real-world recovery.
Almost two decades ago, my one-of-a-kind research on Overactive Bladder diagnosis and treatment led to findings Harvard researchers described as “intriguing.” That experience taught me something fundamental, that even the most localized dysfunctions are rarely local at all. Instead, they’re systemic reflections of the body’s deeper imbalances.
EXOPYR™ was founded to pursue that insight at scale – to develop a precision framework capable of extinguishing inflammation across every biological level, from gene expression to tissue repair.
Every generation of medicine has its inflection point, a moment when the science finally catches up to what patients have been feeling for decades. We believe that moment arrived when inflammation itself became measurable, modifiable, and, in the right conditions, reversible.
A message on the future of inflammation medicine and EXOPYR’s mission to unify diagnostics, biology, and real-world recovery.
Almost two decades ago, my one-of-a-kind research on Overactive Bladder diagnosis and treatment led to findings Harvard researchers described as “intriguing.” That experience taught me something fundamental, that even the most localized dysfunctions are rarely local at all. Instead, they’re systemic reflections of the body’s deeper imbalances.
EXOPYR™ was founded to pursue that insight at scale – to develop a precision framework capable of extinguishing inflammation across every biological level, from gene expression to tissue repair.
Every generation of medicine has its inflection point, a moment when the science finally catches up to what patients have been feeling for decades. We believe that moment arrived when inflammation itself became measurable, modifiable, and, in the right conditions, reversible.
The 2025 Nobel Prize in Medicine recognized the principle of immune tolerance, the body’s natural ability to self-correct when regulation replaces suppression. At EXOPYR™, we’ve built upon that foundation, integrating diagnostics, neuromodulation, and targeted nutraceutical therapeutics into a coherent holistic system that restores biological balance through measurable outcomes.
Our EXOPYR Core Panel Labs™ provide a diagnostic window into four key biological levels: systemic, genetic, metabolic, and repair. These are not isolated readings; they are living indicators of the body’s capacity to regulate itself.
What makes EXOPYR distinct is not a single compound or device. It’s the architecture, how each element interacts in sequence to extinguish inflammation on all four levels. Every nutraceutical in our Concierge Reset Kit™ is available individually, but it’s the precision of the formulation strategy – the timing, ratio, and combinatory logic – that makes the outcome transformative.
In clinical terms, we don’t chase symptoms; we restore control. That’s the central thesis of modern functional medicine, and EXOPYR embodies it at scale.
Each client’s protocol is developed through a functional medicine physician-supervised, data-driven framework that balances quantitative biomarkers with qualitative human experience. We measure what matters, verify results through repeat labs, and refine based on evidence, not ideology.
Our commitment is to clinical integrity, scientific transparency, and patient empowerment. The EXOPYR approach is designed to complement, not compete with, traditional care, by offering a biologically precise roadmap toward genuine resolution, not temporary suppression.
“The future of inflammation medicine is integration.And EXOPYR exists to build that bridge, from lab to life.”
Dr. Justin Mandel, DOM
Founder & Clinical Architect, EXOPYR™
Creator of the Extinguish Inflammation™ protocol
MEDIA INQUIRIES
Press & Speaking Engagements
EXOPYR welcomes inquiries from journalists, producers, and conference organizers seeking insight into the future of inflammation science, immune tolerance, and wellness innovation.
MEDIA INQUIRIES
Press & Speaking Engagements
EXOPYR welcomes inquiries from journalists, producers, and conference organizers seeking insight into the future of inflammation science, immune tolerance, and wellness innovation.
Apply for the Extinguish Inflammation™ Concierge Reset
Enrollment is limited. Begin your personalized evaluation today to see if you qualify for our concierge inflammation reset
Applications reviewed within 24 hours.