EXOPYR Enters TIME’s Best Inventions
St. Petersburg, FL –March 4, 2026 –Extinguish Inflammation™ a newly introduced system-level inflammation reset architecture, has been submitted for consideration in the TIME Best Inventions of 2026 awards,which recognize innovations that are changing how the world works, lives, and heals.TIME Best Inventions is TIME’s annual list of the year’s most exceptional products, services, and breakthroughs reshaping industries and improving lives.
According to Dr. Justin Mandel, DOMthefounder EXOPYR, LLC, Extinguish Inflammation™ wasbuilt on a simple insight: inflammation behaves as a coordinated biological system, yet modern care has historically addressed it through isolated pathways. The EXOPYR framework reorganizes that approach by coordinating intervention across four interdependent levels of biology-systemic signaling, cellular metabolism, gene regulation, and repair capacity.
The program is structured as an eight-week reset architecture verified throughstandardized laboratory testing before and after intervention. Five core biomarkersincluding hs-CRP, fasting insulin, fasting glucose, homocysteine, and uric acidprovide measurable confirmation of physiological change.
“Inflammation has never lacked treatments,” said Dr. Mandel.“What it has lacked is structural coordination. The insight behind EXOPYR is that inflammation functions as a network. When the system is addressed coherently rather than in fragments, outcomes can be measured and verified.”
Unlike conventional approaches that focus on suppressing isolated inflammatory pathways, Extinguish Inflammation sequences interventions across multiple biological levels while maintaining laboratory verification of results. The system was developed to create a governed, repeatable architecture for addressing chronic inflammation.
TIME’s Best Inventions awards highlight products, technologies, and services that demonstrate originality, efficacy, ambition, and impact. Editors evaluate submissions from around theworld across industries including healthcare, technology, sustainability, and consumer innovation.
TIME’s Best Inventions awards highlight products, technologies, and services that demonstrate originality, efficacy, ambition, and impact. Editors evaluate submissions from around theworld across industries including healthcare, technology, sustainability, and consumer innovation.
EXOPYR’ssubmission reflects a broader effort to introduce a new category of inflammation medicine built around coordinated system design and measurable biomarker verification.
Founder-led cohorts of theExtinguish Inflammationprogram are scheduled to open in the second quarter of this yearin limited capacity.More information about the system and the underlying concept that “Inflammation Is a System” can be found at www.EXOPYR.com
About EXOPYR™Extinguish Inflammation™ is EXOPYR’sfour-level inflammation reset system designed to address inflammation as a coordinated biological network rather than isolated pathways. The architecture sequences interventions across systemic signaling, cellular metabolism, gene regulation, and repair capacity, with measurable change verified through standardized biomarker testing.
